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The treatment lasts from 20 to 30 minutes at a time and should be repeated every one to two weeks for maximum effect. Your Gainesville dermatologist may use sclerotherapy to treat your unsightly spider veins. Sclerotherapy involves the injection of a particular chemical agent into the veins to irritate and corrode the vessel walls. The resulting natural healing process causes the veins to shrink and decompose. Typical sclerotherapy treatment begins with a laser vein treatment followed by two sclerotherapy sessions beginning a week after the initial laser treatment.